We have received funding from the European Union (Horizon 2020) and SBRI Healthcare to develop our technology and fund research studies.

We are currently working on studies with the Welsh Wound Innovation Centre, Surgical Materials Testing Laboratory and St Mary's University, Twickenham, to further prove and develop our custom-fit compression.

Below is an overview of the studies we've conducted.


Isobar improves calf venous transit time

University Hospital South Manchester
  • Results demonstrated clearly that applying graduated compression from the ankle to the knee resulted in a significant reduction in the calf venous transit time.
  • Higher pressure produced a greater change in blood flow rate, although it is not a linear relationship.
  • Most currently available flight socks deliver pressures of less than 15mmHg, which is considerably less effective than needed.
  • Read the abstract here

Isobar delivers durability of pressure

Surgical Materials Testing Laboratory, Princess of Wales Hospital, Bridgend

Isobar Compression socks are independently proven to have no drop in pressure after 100 wash cycles.


Isobar delivers comfort and compliance in venous leg ulcer (VLU) treatment

University Hospital South Manchester, David M Riding, Charles McCollum, January 2018

  • Patients with active VLU find Engineered Compression Stockings (Isobar Compression) more comfortable than 4LB, and are more satisfied.
  • For secondary intervention ECS was more comfortable but compliance was no different.
  • Clinical outcomes of ECS in the management of VLU should be evaluated in a definitive multi-centre clinical trial.
Read the abstract here.

Isobar delivers improved outcome for ankle injuries

University Hospital South Manchester
  • Comparison of the impact of using Isobar Compression garments with an Aircast boot versus tubigrip and Aircast boot in the treatment of ankle fractures.
  • All patients randomised to the boot plus Isobar Compression stockings demonstrated much better outcomes according to all of the assessment measures.
  • Click here to download the presentation
  • Read a patient case study here

Isobar delivers accurate pressure

Funded by Innovate UK, conducted at the Welsh Wound Innovation Centre, 2017

  • The mean pressure for Isobar Compression was within range
  • The mean pressure for the leading medical brand was out of range 
  • Isobar is 5x more likely to deliver the stated pressure than the leading medical compression brand
“The finding that commercially available bandages often apply higher than anticipated sub bandage pressures was previously noted by Partsch et al (2008) and the present study suggests commercially available compression stockings may also apply higher than anticipated pressures. The 3D scanned stockings were more likely to apply compression anticipated by a class II stocking.” Michael Clark, Welsh Wound Innovation Centre

Health economics and optimising pressure profiles

Funded by SBRI/Health East of England

Advanced Therapeutic Materials has received research funding from SBRI/Health East of England to carry out research and development work with our proprietary technology as part of a drive to bring innovative treatments into the NHS to improve outcomes, increase efficiency and reduce costs.

This funding has contributed significantly to the development of our treatment system for managing the symptoms of Chronic Venous Insufficiency. As part of this project, we were able to commission a report from an independent Health Economist which has indicated significant potential for cost savings compared to treatment with multi-layer compression bandages.  

Another significant part of the project has enabled Advanced Therapeutic Materials to understand better the relationship between applied pressure and the impact on venous return rates which is vital for improving treatment by optimising the pressure profile to achieve the desired therapeutic effect whilst achieving a high level of comfort which in turn encourages concordance. It would not have been possible to carry out this research effectively had our technology not been able to deliver the specified pressures accurately across the whole limb.


Lymphoedema study

Funded by SBRI/Health East of England

Advanced Therapeutic Materials has undertaken a research project funded by SBRI for Health East of England to work with a specialist Lymphoedema clinic to develop garments with improved fit and greater comfort without sacrificing clinical efficacy.