Advanced Therapeutic Materials Ltd, the company behind Isobar, is actively involved in evidence-based research to prove the effectiveness of the Isobar system. Below is an overview of the studies we've conducted.


Health economics and optimising pressure profiles

Funded by SBRI/Health East of England

Advanced Therapeutic Materials has received research funding from SBRI/Health East of England to carry out research and development work with our proprietary technology as part of a drive to bring innovative treatments into the NHS to improve outcomes, increase efficiency and reduce costs.

This funding has contributed significantly to the development of our treatment system for managing the symptoms of Chronic Venous Insufficiency. As part of this project, we were able to commission a report from an independent Health Economist which has indicated significant potential for cost savings compared to treatment with multi-layer compression bandages.  

Another significant part of the project has enabled Advanced Therapeutic Materials to understand better the relationship between applied pressure and the impact on venous return rates which is vital for improving treatment by optimising the pressure profile to achieve the desired therapeutic effect whilst achieving a high level of comfort which in turn encourages concordance. It would not have been possible to carry out this research effectively had our technology not been able to deliver the specified pressures accurately across the whole limb.


Lymphoedema study

Funded by SBRI/Health East of England

Advanced Therapeutic Materials has undertaken a research project funded by SBRI for Health East of England to work with a specialist Lymphoedema clinic to develop garments with improved fit and greater comfort without sacrificing clinical efficacy.


Calf venous transit time study

Research by University Hospital South Manchester

A study was conducted at University Hospital South Manchester to measure the effect of different pressures at the ankle on the venous return rate in the calf. The results demonstrated clearly that applying graduated compression from the ankle to the knee resulted in a significant reduction in the calf venous transit time. Furthermore it showed that higher pressure produced a greater change in blood flow rate, although it is not a linear relationship.

The study also found that most currently available flight socks deliver pressures of less than 15mmHg, which is considerably less effective than needed.

Read the abstract here


Ankle injury study

University Hospital South Manchester

Research was also carried out at University Hospital South Manchester to compare the impact of using Advanced Therapeutic Materials' compression stockings with an Aircast boot versus tubigrip and Aircast boot in the treatment of ankle fractures. The results were very encouraging. All patients randomised to the boot plus compression stockings demonstrated much better outcomes according to all of the assessment measures.

Click here to download the presentation